CORVALEN
Corvalen is a nutritional supplement formulated to help restore and maintains cellular core energy.
D-Ribose, the active ingredient in Corvalen is a key component of ATP, the energy currency of cells, and is clinically proven to restore cellular energy needed to promote healthy tissue function, increase exercise tolerance and improve quality of life. D-Ribose supplementation has been shown to boost heart muscle function following heart attacks, and to improve blood pumping in people with congestive heart failure
Better heart muscle function after D-Ribose supplementation leads to better delivery of energy rich blood to skeletal muscles, prepping for increased activity.
This unique, safe and clinically proven formulation accelerates your body’s own natural processes of energy synthesis and utilization.
Corvalen is the only clinically tested and validated D-Ribose formulation.
REDUCES FATIGUE, MUSCLE PAIN, SORENESS AND STIFFNESS associated with reduced cellular energy.
SUPPORTS HEART HEALTH
CLINICALLY PROVEN IN FIBROMYALGIA & CHRONIC FATIGUE INDIVIDUALS
SELECTED LIST OF CLINICAL STUDIES
- Coronary Artery Disease
A randomized, double blind, placebo controlled clinical trial with 20 patients with coronary artery disease and stable angina (chest pain).
RESULTS:- D-Ribose increased treadmill walking time to ST segment depression; nearly 20% greater improvement versus placebo
- After 3 days, also improved the heart's tolerance to ischemia.
- Coronary Artery Disease/ Congestive Heart Failure
Prospective, randomized, double blind, placebo controlled, crossover design study to assess effects of D-ribose supplementation in 15 patients with coronary artery disease and congestive heart failure (Class II – III).
RESULTS:- D-Ribose led to an enhancement of atrial contribution to left ventricular filling, a smaller left atrial dimension, and a shortened E wave deceleration by echocardiography
- Resulted in a 12% increase in quality of life as measured on validated scale.
- Congestive Heart Failure (CHF)
Clinical trial with 14 congestive heart failure patients (NYHA Class II – III) was enrolled in a double blind, placebo controlled, crossover design. Maximal cycle ergometry with gas exchange was monitored pre- and post- each treatment period.
RESULTS:- With exercise, D-ribose-treated CHF patients maintain better ventilatory efficiency, a strong predictor of heart failure survival
- Also improved VO2max, reduced shortness of breath, increased exercise tolerance, and increased hypoxic threshold vs. placebo.
- Open Heart Surgery
A randomized, double blind clinical trial with 27 open heart patients.
RESULTS:- Ejection fraction in placebo group significantly depressed following 7-days of post-surgical recovery
- At 7 days, 80% of placebo group demonstrated decline, whereas only 20% of the D-ribose group experienced decline.
- Coronary Artery Disease
A comparison of the results of 143 patients receiving D-ribose as an oral “pre-op” versus 40 historical patients following a similar protocol, without supplementation.
RESULTS:- “Off” pump cardiopulmonary bypass with supplemental ribose resulted in no peri-operative deaths and no post-operative myocardial infarctions
- Ribose treated patients showed a 43% improvement in cardiac index (cardiac output/surface area) vs. 13% with historical controls without ribose.
- Congestive Heart Failure
An 8-week open-label clinical trial with 15 congestive heart failure patients (Class III (9) and IV (6)) undergoing cardiopulmonary testing.
RESULTS:- O2 uptake efficiency, stroke volume (O2 pulse), and ventilatory efficiency, the most powerful predictor of patient survival, were significantly improved following supplementation with D-ribose.
- Chronic Fatigue Syndrome/ Fibromyalgia
Open-label uncontrolled pilot study involving 41 participants.
RESULTS:- Subjective patient questionnaires revealed significant improvement in all five visual analog scale (VAS) categories: energy; sleep; mental clarity; pain intensity; and well-being
- Improvement in patients' global assessment also demonstrated
- Approximately 66% of patients experienced significant improvement, with an average increase in energy on the VAS of 45% and an average improvement in overall well-being of 30% (p < 0.0001).
Increased ATP levels in skeletal muscle following Corvalen supplementation helps to reduce muscle pain and fatigue.
SUPPLEMENTAL Corvalen:
- Builds ATP levels.
- Reduces fatigue.
- Speeds energy recovery.
- Maintains balanced of tissue energy.
- Put stressed muscle in better physiological conditions.
- Improved function of stressed tissues.
- Enhance function of cardiac tissues.
Corvalen main ingredient Bioenergy’s D-Ribose has achieved GRAS (Generally Recognized as Safe) from US FDA based on submitted data on efficacy, safety and manufacturing process.
Bioenergy D-Ribose is safe, clinically proven to be effective, and is protected by a family of patents covering all known uses of ribose in nutrition and medicine. Although Bioenergy D-Ribose is a five-carbon monosaccharide, it does not raise blood sugar. Bioenergy D-Ribose is highly soluble in either hot or cold solutions and tastes slightly sweet.
RECOMMENDED DOSING
Corvalen will temporarily depress blood sugar several points for an hour after ingestion. This is usually sub-clinical. However, it is recommended Corvalen be taken with food, juice or around meal time to avoid potential symptoms of hypoglycemia.
Cardiac Health
- Congestive Heart Failure/Ischemic Heart Disease
- 5 grams, twice daily
- 5 grams, 3 times daily for advanced stages
- Atrial Fibrillation
- 5 grams, 2-3 times daily
- General heart health
- 3 to 5 grams once to twice daily
Fibromyalgia/ Chronic Fatigue
- 5 grams, 3 times daily for the first 2-3 weeks. After that, the dose may be reduced to twice daily for maintenance.
Restless Leg Syndrome and other chronic muscle problems
- 5 grams, 2 to 3 times daily as needed.
Athletics/Exercise/Endurance
- 5 grams, 2 times daily
- Take 30-45 minutes before and after exercise/physical activity
- Additional doses may be taken during the activity if the duration of exercise is prolonged (several hours).
Fatigue
- 3 grams, twice daily